Dr Csanad Bachrati from the School of Life Sciences will lead the next LIH Research Development Seminar entitled, Maintenance of Genome Integrity in Cell Physiology and Disease.

11.45am to 2.00pm* Wednesday 26th July 2017, David Chiddick Building, Room DCB0101

It is estimated that around 100’000 DNA lesions are generated in every cell of the human body daily. This is a huge burden, and the fact that cells survive this with relatively minor consequences is down to the efficiency of a number of cellular processes the role of which is to maintain the integrity of the genome. If the function of any of these pathways is impaired, for example due to inactivating somatic or inherited germline mutations, the accumulating lesions can be fixed through mutagenic pathways resulting in diseases commonly termed genome instability syndromes. Symptoms of these syndromes include a high incidence of cancer. In addition, if a gene product is involved in the maintenance of the mitochondrial genome mutations can lead to mitochondrial DNA depletion syndromes. In this seminar I will give a generic overview of some of these cellular processes, then discuss results from my laboratory that demonstrate the role of impaired DNA replication initiation in the development of osteosarcoma, the potential involvement of five new gene products in breast cancer development, and the role of a less characterised topoisomerase in the maintenance of the mitochondrial genome.

The LIH extends a warm welcome to all interested in this exciting area.

*11.45 to 1.00pm presentation with Q&A, 1.00pm to 2.00pm optional discussion and action planning