Research by scientists at the University of Lincoln has been published in a leading journal from the Royal Society of Chemistry.
The new academic paper, titled Synthesis of a bicyclic oxo-c-lactam from a simple caprolactam derivative, features in the New Journal of Chemistry.
The research was carried out by Dr Tobias Gruber from the School of Pharmacy and Dr Elisa Nauha from the School of Chemistry at Lincoln, together with colleagues from the Technische Universität Bergakademie Freiberg in Germany and the University of Oxford, UK.
The synthesis of the 6-azabicyclo[3.2.1]octane ring system, via Dieckmann cyclization, is described. Ring closure involves reaction of a caprolactam enolate with a C-6 ester, the reactive axial conformation of which is promoted by the presence of an N-tert-butyloxycarbonyl group on the lactam nitrogen. The results will enable the synthesis of new bridged caprolactams for testing as antibacterials and nucleophilic enzyme inhibitors.
To read the paper in full, visit the journal website.